Food selection is important for metabolic homeostasis and is influenced by multiple factors such as stress and nutritional state. The molecular mechanisms underlying selection between a high-carbohydrate diet and a high-fat diet remain unknown. The present study shows that AMPK in the paraventricular hypothalamus regulates food preference through carnitine palmitoyltransferase 1c. In mice that haven’t eaten for a while, this manifests as selection of carbs over fats, possibly because carbs are better able to normalize ketone levels that have risen during fasting. Check out the paper at: http://www.cell.com/cell-reports/S2211-1247(17)31786-2.
Shiki Okamoto, Tatsuya Sato, Michihiro Tateyama, Haruaki Kageyama, Yuko Maejima, Masanori Nakata, Satoshi Hirako,7 Takashi Matsuo,1,8 Sanda Kyaw,1,9 Tetsuya Shiuchi, et al. (2018). Activation of AMPK-Regulated CRH Neurons in the
PVH is Sufficient and Necessary to Induce Dietary
Preference for Carbohydrate over Fat. Cell Reports 22.
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