Food selection is important for metabolic homeostasis and is influenced by multiple factors such as stress and nutritional state. The molecular mechanisms underlying selection between a high-carbohydrate diet and a high-fat diet remain unknown. The present study shows that AMPK in the paraventricular hypothalamus regulates food preference through carnitine palmitoyltransferase 1c. In mice that haven’t eaten for a while, this manifests as selection of carbs over fats, possibly because carbs are better able to normalize ketone levels that have risen during fasting. Check out the paper at: http://www.cell.com/cell-reports/S2211-1247(17)31786-2.
Shiki Okamoto, Tatsuya Sato, Michihiro Tateyama, Haruaki Kageyama, Yuko Maejima, Masanori Nakata, Satoshi Hirako,7 Takashi Matsuo,1,8 Sanda Kyaw,1,9 Tetsuya Shiuchi, et al. (2018). Activation of AMPK-Regulated CRH Neurons in the
PVH is Sufficient and Necessary to Induce Dietary
Preference for Carbohydrate over Fat. Cell Reports 22.
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Great paper and animations. Unfortunately, the thick accent of the speaker makes the narration challenging to understand.
Very interessting and good video but had to watch it three times because it was difficult to understand the language. If you turn on the subtitle, it shows the wrong words (eg. fasting = passing) etc.